Subphenotypes of severe early-onset pre-eclampsia at hospital admission. A Latin American single-center exploratory latent class analysis.

Jose Rojas-SuarezJavier A CarvajalMaria P EchavarriaIsabella RamosMaria A ZambranoMaria A HincapieEvelyn E PeñaLaura LibrerosMaría F Escobar

Published in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2023)

We identified two distinct subphenotypes in a Latin American cohort of patients with severe early-onset pre-eclampsia. Subphenotype 2, characterized by higher TPR, sFlt-1, and serum creatinine and lower CO and PlGF at admission, was associated with worse maternal outcomes and appeared less modifiable after in-hospital treatment.

Keyphrases

early onset
late onset
emergency department
healthcare
adverse drug
birth weight
pregnant women
pregnancy outcomes
combination therapy
adipose tissue