The effect of short-course antibiotics on the resistance profile of colonizing gut bacteria in the ICU: a prospective cohort study.

Christian MunckRavi U ShethEdward CuaresmaJessica WeidlerStephania L StumpPhilip ZachariahDavid H ChongAnne-Catrin UhlemannJulian A AbramsHarris H WangDaniel E Freedberg

Published in: Critical care (London, England) (2020)

Short-course ICU antibiotics made little detectable difference in the antimicrobial resistance pattern of colonizing gut bacteria over 72 h in the ICU. This provides an improved understanding of the dynamics of antimicrobial resistance in the ICU and some reassurance that short-course antibiotics may not adversely impact the stewardship goal of reducing antimicrobial resistance.

Keyphrases

antimicrobial resistance
intensive care unit
mechanical ventilation
acute respiratory distress syndrome
acute care