Pathogenicity and virulence of <i>Rickettsia</i>.
Luke HelminiakSmruti MishraHwan Keun KimPublished in: Virulence (2022)
Rickettsiae include diverse Gram-negative microbial species that exhibit obligatory intracellular lifecycles between mammalian hosts and arthropod vectors. Human infections with arthropod-borne <i>Rickettsia</i> continue to cause significant morbidity and mortality as recent environmental changes foster the proliferation of arthropod vectors and increased exposure to humans. However, the technical difficulties in working with <i>Rickettsia</i> have delayed our progress in understanding the molecular mechanisms involved in rickettsial pathogenesis and disease transmission. Recent advances in developing genetic tools for <i>Rickettsia</i> have enabled investigators to identify virulence genes, uncover molecular functions, and characterize host responses to rickettsial determinants. Therefore, continued efforts to determine virulence genes and their biological functions will help us understand the underlying mechanisms associated with arthropod-borne rickettsioses.
Keyphrases
- biofilm formation
- gram negative
- pseudomonas aeruginosa
- escherichia coli
- staphylococcus aureus
- antimicrobial resistance
- genome wide
- multidrug resistant
- endothelial cells
- cystic fibrosis
- candida albicans
- signaling pathway
- microbial community
- bioinformatics analysis
- gene therapy
- induced pluripotent stem cells
- gene expression
- genetic diversity