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Highly Enantioselective Synthesis of Fused Tri- and Tetrasubstituted Aziridines: aza-Darzens Reaction of Cyclic Imines with α-Halogenated Ketones Catalyzed by Bifunctional Phosphonium Salt.

Jianke PanJia-Hong WuHongkui ZhangXiaoyu RenJian-Ping TanLixiang ZhuHong-Su ZhangChunhui JiangTianli Wang
Published in: Angewandte Chemie (International ed. in English) (2019)
The first enantioselective aza-Darzens reaction of cyclic imines with α-halogenated ketones was realized under mild reaction conditions by using amino-acid-derived bifunctional phosphonium salts as phase-transfer promoters. A variety of structurally dense tri- and tetrasubstituted aziridine derivatives, containing benzofused heterocycles as well as spiro-structures, were readily synthesized in high yields with excellent diastereo- and enantioselectivities (up to >20:1 d.r. and >99.9 % ee). The highly functionalized aziridine products could be easily transformed into different classes of biologically active compounds.
Keyphrases
  • ionic liquid
  • amino acid
  • electron transfer
  • room temperature
  • highly efficient
  • high resolution
  • mass spectrometry
  • molecularly imprinted