Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway.

Hui ZhangJinyi LinYihui ShenJianan PanChunhui Wang Lei-Lei Cheng

Published in: Journal of inflammation research (2022)

By reversing the pyroptosis in cardiomyocytes, crocin treatment in a mouse model exerted great potential to aid in the prevention of ICIs-related myocarditis from a novel target.

Keyphrases

mouse model
nlrp inflammasome
signaling pathway
oxidative stress
lps induced
immune response
cell proliferation
inflammatory response
combination therapy
nuclear factor
climate change
toll like receptor
endothelial cells
drug induced