Extracellular Vesicle-Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells.

Xiao-Qing LiRui ZhangHong LuXiao-Min YueYu-Fan Huang

Published in: Cancer research (2022)

This study provides mechanistic insights into the generation of an osteogenic premetastatic niche by breast cancer-derived EVs and identifies potential EV-derived diagnostic biomarkers and targets for breast cancer bone metastasis.

Keyphrases

breast cancer cells
bone mineral density
mesenchymal stem cells
soft tissue
bone loss
bone marrow
bone regeneration
genome wide
postmenopausal women
gene expression
body composition
risk assessment
climate change