Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19.

Chuang GuoMingming WuBeibei HuangRui ZhaoLinlin JinBinqing FuPing WangDongyao WangMeijuan ZhengJingwen FangHaiming WeiKun QuFang Ni

Published in: Genome medicine (2022)

We identified a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19. Our results identify memory-like NK2.1 cells as a potential target for developing immunotherapies for infectious diseases and for addressing age-related dysfunctions of the immune system.

Keyphrases

nk cells
single cell
coronavirus disease
infectious diseases
sars cov
working memory
rna seq
high throughput
genome wide
respiratory syndrome coronavirus