Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still's disease from sepsis.

Tomohiro KogaRemi SumiyoshiKaori FurukawaShuntaro SatoKiyoshi MigitaToshimasa ShimizuMasataka UmedaYushiro EndoShoichi FukuiShin-Ya KawashiriNaoki IwamotoKunihiro IchinoseMami TamaiHideki NakamuraTomoki OriguchiFumiaki NonakaAkihiro YachieHideaki KondoTakahiro MaedaAtsushi Kawakami

Published in: Arthritis research & therapy (2020)

Determination of FGF-2 and IL-18 levels in combination may represent a biomarker for the differential diagnosis of AOSD from sepsis, based on the measurement of multiple cytokines.

Keyphrases

septic shock
acute kidney injury
intensive care unit
solid phase extraction
molecularly imprinted
tandem mass spectrometry