Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis.
Cyrus DaruwallaVahid ShaygannejadSerkan OzakbasEva Kubala HavrdovaDana HorákováRaed AlroughaniCavit BozFrancesco PattiMarco OnofrjAlessandra LugaresiSara EichauMarc GirardAlexandre PratPierre DuquetteBassem YamoutSamia J KhourySeyed Aidin SajediRecai TurkogluAyse AltintasOlga SkibinaKatherine BuzzardPierre GrammondRana KarabudakAnneke Van Der WaltHelmut ButzkuevenDavide MaimoneJeannette Lechner-ScottAysun SoysalNevin JohnJulie PrevostDaniele SpitaleriCristina Ramo-TelloOliver GerlachGerardo IulianoMatteo FoschiRadek AmpapaVincent van PeschMichael Harry BarnettNevin ShalabyMarie D'hoogheJens KuhleMaria Jose SaMarzena Fabis-PedriniAllan KermodeSaloua MrabetRiadh GouiderSuzanne HodgkinsonGuy LaureysLiesbeth Van HijfteRichard MacdonellCelia Oreja-GuevaraEdgardo CristianoPamela McCombeJose Luis Sanchez-MenoyoBhim SinghalYolanda BlancoStella HughesJustin GarberClaudio SolaroChris McGuiganBruce TaylorKoen de GansMario HabekAbdullah Al-AsmiSimu MihaelaTamara Castillo TriviñoTalal Al-HarbiJuan Ignacio RojasOrla GrayDheeraj KhuranaBart Van WijmeerschNikolaos GrigoriadisJihad S InshasiJiwon OhEduardo Aguera-MoralesYara Dadalti FragosoFraser MooreCameron ShawSeyed Mohammad BaghbanianNeil ShueyBarbara WillekensTodd A HardyDanny DecooAngel Perez SempereDeborah FieldRay Wynford-ThomasNick G CunniffeIzanne RoosCharles B MalpasAlasdair J ColesTomas KalincikJames William L BrownPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)
This study suggests that early non-disabling relapses are associated with a higher risk of disability accumulation than no early relapses in RRMS. This risk may be mitigated by high-efficacy DMTs. Therefore, non-disabling relapses should be considered when making treatment decisions.