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[The structure of pathogenic germline variants in colorectal cancer in Moscow patients].

A B SemenovaM M ByakhovaMaria MakarovaMarina V NemtsovaD K ChernevskiyA M DanishevichV G ShatalovA V BabkinaN G PopovaS M Gadzhieva
Published in: Arkhiv patologii (2023)
According to the results of the study, an earlier manifestation of a malignant neoplasm and a more frequent occurrence of high-grade carcinomas in the presence of pathogenic germline mutations were noted compared to the group of patients without clinically significant varianrs, while in the group with identified mutations, the frequency of regional and distant metastasis was not increased.
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