BNIP3-mediated autophagy via the mTOR/ULK1 pathway induces primordial follicle loss after ovarian tissue transplantation.

Published in: Journal of assisted reproduction and genetics (2023)

BNIP3-induced autophagy is crucial in primordial follicle loss during OTT procedure, and BNIP3 is a potential therapeutic target for primordial follicle loss after OTT.

Keyphrases

germ cell
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
diabetic rats
high glucose
stem cells
cell therapy
endothelial cells
stress induced