Imidazole-carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging.

Thanh Chung PhamDong Joon LeeDo Hun KimJuyoung Yoon Tran Dai Lam Hwan Myung Kim Songyi Lee

Published in: Chemical communications (Cambridge, England) (2023)

A heavy-atom-free photosensitizer (CI) based on an imidazole-carbazole conjugate exhibited strong fluorescence emission and ROS generation via both type I and II mechanisms. In particular, CI showed efficient photodynamic therapy and fluorescence bioimaging under two-photon (TP) excitation (740 nm) toward HeLa cells with negligible dark toxicity.

Keyphrases

photodynamic therapy
energy transfer
living cells
single molecule
quantum dots
fluorescence imaging
cell cycle arrest
fluorescent probe
cell death
induced apoptosis
cancer therapy
dna damage
oxidative stress
molecular dynamics
drug delivery
reactive oxygen species
electron transfer
signaling pathway