Rapamycin Controls Lymphoproliferation and Reverses T-Cell Responses in a Patient with a Novel STIM1 Loss-of-Function Deletion.
Ibrahim Serhat KarakusMehmet Cihangir CatakAlexandra FrohneFeyza Bayram CatakMelek Yorgun AltunbasRoyala BabayevaSevgi Kostel BalSevgi Bilgic EltanEzgi Yalcin GungorenFehim EsenItir Ebru ZemheriElif Karakoc-AydinerAhmet OzenSuar Caki-KilicMichael J KraakmanKaan BoztugSafa BarışPublished in: Journal of clinical immunology (2024)
This study enhances our understanding of STIM1 deficiency by uncovering additional abnormal T-cell responses, and reveals for the first time the potential therapeutic utility of rapamycin for this disorder.
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