DNA methylation of exercise-responsive genes differs between trained and untrained men.
Carla GeigerMaria NeedhamsenEric B EmanuelssonJessica NorrbomKaren SteindorfCarl Johan SundbergStefan M ReitznerMaléne E LindholmPublished in: BMC biology (2024)
Endurance- compared to resistance-trained athletes and untrained individuals demonstrated a different DNA methylation signature of selected skeletal muscle genes, which may influence transcriptional dynamics following a bout of acute exercise. Skeletal muscle fiber type distribution is associated with methylation of fiber type specific genes. Our results suggest that the baseline DNA methylation landscape in skeletal muscle influences the transcription of regulatory genes in response to an acute exercise bout.
Keyphrases
- genome wide
- skeletal muscle
- dna methylation
- resistance training
- high intensity
- gene expression
- insulin resistance
- body composition
- liver failure
- genome wide identification
- transcription factor
- bioinformatics analysis
- physical activity
- copy number
- drug induced
- respiratory failure
- genome wide analysis
- metabolic syndrome
- cancer therapy
- single cell
- drug delivery
- oxidative stress
- hepatitis b virus