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Immune Checkpoint Inhibitors and the Kidney: A Focus on Diagnosis and Management for Personalised Medicine.

Elisa LonghitanoPaola MuscolinoClaudia Lo ReSerena Ausilia FerraraValeria CernaroGuido GembilloDalila TessitoreDesirèe SperanzaFrancesco FiguraMariacarmela SantarpiaNicola SilvestrisDomenico SantoroTindara Franchina
Published in: Cancers (2023)
Immunity plays a crucial role in fighting cancer, but tumours can evade the immune system and proliferate and metastasize. Enhancing immune responses is a new challenge in anticancer therapies. In this context, efficacy data are accumulating on immune checkpoint inhibitors and adjuvant therapies for various types of advanced-stage solid tumours. Unfortunately, immune-related adverse events are common. Although infrequent, renal toxicity may occur via several mechanisms and may require temporary or permanent drug suspension, renal biopsy, and/or immunosuppressive treatment. This short review aims to provide a practical approach to the multidisciplinary management of cancer patients with renal toxicity during treatment with immune checkpoint inhibitors.
Keyphrases
  • papillary thyroid
  • immune response
  • oxidative stress
  • squamous cell
  • early stage
  • lymph node metastasis
  • squamous cell carcinoma
  • electronic health record
  • toll like receptor
  • emergency department
  • dendritic cells