Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring-the heart as a target for fetal programming in rats.
Till SchütteSarah M KedzioraNadine HaaseFlorian HerseNatalia V AleninaDominik N MullerMichael BaderMichael SchuppRalf DechendMichaela GolicKristin KräkerPublished in: Diabetologia (2021)
Diabetic pregnancy in rats induces cardiac dysfunction, left ventricular hypertrophy and altered proinflammatory status in adult offspring only after a high-fat diet. A diabetic pregnancy itself was not sufficient to impair myocardial function and gene expression in male offspring later in life. This suggests that a postnatal high-fat diet is important for the development of cardiac dysfunction in rat offspring after diabetic pregnancy. Our data provide evidence that a diabetic pregnancy is a novel cardiac risk factor that becomes relevant when other challenges, such as a high-fat diet, are present.
Keyphrases
- high fat diet
- left ventricular
- insulin resistance
- adipose tissue
- type diabetes
- preterm birth
- wound healing
- gene expression
- pregnancy outcomes
- heart failure
- oxidative stress
- risk factors
- acute myocardial infarction
- cardiac resynchronization therapy
- aortic stenosis
- preterm infants
- pregnant women
- skeletal muscle
- mitral valve
- left atrial
- big data
- atrial fibrillation
- aortic valve
- transcatheter aortic valve replacement
- coronary artery disease
- percutaneous coronary intervention