Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis.

Renata Černá PařízkováJiřina MartínkováEduard HavelPetr ŠafránekMilan KaškaDavid AstapenkoJan BezouškaJaroslav ChládekVladimír Černý

Published in: Critical care (London, England) (2021)

These findings emphasize the importance of TDM and a cautious approach to augmented maintenance dosing of meropenem to patients with FO infected with less susceptible pathogens, if guided by population covariate relationships between CLme and creatinine clearance.

Keyphrases

gram negative
multidrug resistant
intensive care unit
acute kidney injury
low dose
septic shock
uric acid
metabolic syndrome
virtual reality