B Cell Depletion Inhibits Fibrosis via Suppression of Profibrotic Macrophage Differentiation in a Mouse Model of Systemic Sclerosis.

Hiroko NumajiriAi KuzumiTakemichi FukasawaSatoshi EbataAsako Yoshizaki-OgawaYoshihide AsanoYutaka KazoeKazuma MawatariTakehiko KitamoriAyumi YoshizakiShinichi Sato

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

These findings suggest that B cell depletion inhibits tissue fibrosis via suppression of profibrotic macrophage differentiation in mice with BLM-SSc, providing a new rationale for B cell depletion therapy in SSc.

Keyphrases

systemic sclerosis
interstitial lung disease
mouse model
adipose tissue
clinical trial
stem cells
type diabetes
liver fibrosis
metabolic syndrome
mesenchymal stem cells
cell therapy
skeletal muscle