Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function.

Lorien G SalyerHussam E SalhiElizabeth A BrundageVikram ShettigarSarah L SturgillHelena ZanellaBenjamin TempletonEaman AbayKathryn M EmmerJeovanna Lowe Jill A Rafael-Fortney Narasimham L Parinandi D Brian Foster Timothy A McKinsey Kathleen C Woulfe Mark T Ziolo Brandon J Biesiadecki

Published in: Circulation research (2023)

We have demonstrated that tyrosine kinase phosphorylation of TnI is a novel mechanism to directly and beneficially accelerate myocardial relaxation in vivo.

Keyphrases

tyrosine kinase
left ventricular
epidermal growth factor receptor
protein kinase
blood pressure
single molecule
atrial fibrillation