Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance.

Han-Ying ChengChia-Hsin HsiehPo-Han LinYu-Tung ChenDennis Shin-Shian HsuShyh-Kuan TaiPen-Yuan ChuMuh-Hwa Yang

Published in: Journal for immunotherapy of cancer (2022)

This finding reveals the mechanism of EMT-mediated resistance beyond cancer stemness through modulation of post-treatment inflammasome activity. It also highlights the dynamic remodeling of the TME throughout metastatic evolution.

Keyphrases

nlrp inflammasome
epithelial mesenchymal transition
signaling pathway
stem cells
papillary thyroid
squamous cell carcinoma
small cell lung cancer
transcription factor
lymph node metastasis