An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.

Zhipei LiuFeng WangHui YuanFuyun TianChuanyan YangFei HuYiyao LiuMeiqin TangMeixuan PingChunlan KangTing LuoGuimei YangMei HuZhaobing GaoPing Li

Published in: BMC biology (2024)

Our data provide evidence that a potential cooperation mechanism in the extracellular vestibule of the VSD and the PD would determine the gating polarity in hERG.

Keyphrases

electronic health record
big data
human health
machine learning
risk assessment
climate change
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artificial intelligence
deep learning
drug induced