Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort.
Mark M G MulderJoep SchellensJan-Willem E M SelsFrank van RosmalenAnne-Marije HulshofFemke de VriesRuud SegersCasper MihlWalther N K A van MookAalt BastHenri M H SpronkYvonne M C HenskensIwan C C van der HorstHugo Ten CateLeon J SchurgersMarjolein DrentBas C T van BusselPublished in: Journal of intensive care (2023)
ICU mortality in COVID-19 patients was associated with higher dp-ucMGP levels over 4 weeks, independent of age, gender, and APACHE II score, and not explained by inflammation, renal function, history of coumarin use, and CAC score. No association with PE was observed. At ETI, higher levels of dp-ucMGP were associated with higher OR for both ICU and six month mortality in crude and adjusted modes, although not statistically significantly.