Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo.

Anna RichterSina SenderAnnemarie LenzRico SchwarzBurkhard HinzGudrun KnuebelAnett SekoraHugo Murua EscobarChristian JunghanssCatrin Roolf

Published in: BMC cancer (2020)

The CK2 inhibitor CX-4945 has limited clinical effects in an in vivo B-ALL xenograft model when applied as a single drug over a six day period. However, gene expression in B-ALL cells was altered and suggested effects on apoptosis via downregulation of BCL6. Unexpectedly, the BCL6 opponent BACH2 was also reduced. Interactions and regulation loops have to be further evaluated.

Keyphrases

cell cycle arrest
cell death
gene expression
induced apoptosis
endoplasmic reticulum stress
protein kinase
oxidative stress
dna methylation
signaling pathway
cell proliferation
tyrosine kinase
anti inflammatory
drug induced