[The efficacy and safety of intra-articular application of a combination of sodium hyaluronate and chondroitin sulfate for osteoarthritis of the knee: a multicenter prospective study].
L I AlekseevaN G KashevarovaE A TaskinaE P SharapovaS G AnikinE A StrebkovaT A RaskinaE V ZonovaE N OttevaSvetlana RodionovaA N TorgashinU V BuklemishevE I ShmidtPavel A ShesternyaA V NaumovN V ZagorodniyAlexander M LilaPublished in: Terapevticheskii arkhiv (2020)
These results suggest that intra-articular injections of hyaluronic acid plus chondroitin sulfate in patients with knee OA are efficient and safe. A single injection of the drug resulted in statistically significant reduction of pain and stiffness, reduction in NSAIDs intake, as well as improvement in patients quality of life and function.
Keyphrases
- hyaluronic acid
- knee osteoarthritis
- total knee arthroplasty
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic pain
- chronic kidney disease
- ultrasound guided
- rheumatoid arthritis
- prognostic factors
- pain management
- neuropathic pain
- peritoneal dialysis
- emergency department
- anterior cruciate ligament reconstruction
- body mass index
- physical activity
- double blind
- adverse drug