Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1 α Branch of the Endoplasmic Reticulum Stress Response.

Ruixi LuoYaqiong WeiPeng ChenJing ZhangLa WangWenjia WangPing WangWeiyi Tian

Published in: Stem cells international (2023)

-XBP1 pathway may play a critical role in this effect. The current study provides novel insight for the application of MSCs for IPF treatment and elucidates the mechanism underlying the preventive effects of MSCs against pulmonary fibrosis.

Keyphrases

mesenchymal stem cells
endoplasmic reticulum
umbilical cord
pulmonary fibrosis
bone marrow
idiopathic pulmonary fibrosis
cell therapy
signaling pathway
endoplasmic reticulum stress
replacement therapy