Sickle cell screening in Uganda: High burden, human immunodeficiency virus comorbidity, and genetic modifiers.
Charles KiyagaArielle G HernandezIsaac SsewanyanaBeverly A SchaeferKathryn E McElhinneyGrace NdeeziThad A HowardChristopher M NdugwaRussell E WareJane R AcengPublished in: Pediatric blood & cancer (2019)
High sickle cell burden and potential HIV comorbidity are confirmed in Uganda. Genetic modifiers are common and likely influence laboratory and clinical phenotypes. These prospective data document that targeted sickle cell screening is feasible and effective in Uganda, and support development of district-level comprehensive care programs.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hepatitis c virus
- hiv infected
- hiv positive
- hiv aids
- healthcare
- genome wide
- risk factors
- palliative care
- copy number
- public health
- electronic health record
- quality improvement
- cancer therapy
- hiv testing
- dna methylation
- climate change
- risk assessment
- pain management
- human health