Molecular and cellular paradigms of multidrug resistance in cancer.
Foram U VaidyaAbu Sufiyan ChhipaVinita MishraVishal Kumar GuptaShiv Govind RawatAjay KumarChandramani PathakPublished in: Cancer reports (Hoboken, N.J.) (2020)
MDR is an outcome of interplays between multiple intricate pathways responsible for the inactivation of drug and development of resistance. MDR is a major obstacle in regimens of successful application of anti-cancer therapy. An improved understanding of the molecular mechanism of multi drug resistance and cellular reprogramming can provide a promising opportunity to combat drug resistance in cancer and intensify anti-cancer therapy for the upcoming future.