Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells.

Alberto Marti-RodrigoFernando AlegreÁngela B MoragregaFrancisco García-GarcíaPablo Martí-RodrigoAnabel Fernández-IglesiasJordi Gracia-SanchoNadezda ApostolovaJuan V EspluguesAna Blas-Garcia

Published in: Gut (2019)

RPV ameliorates liver fibrosis through selective STAT1-dependent induction of apoptosis in HSC, which exert paracrinal effects in hepatocytes, thus promoting liver regeneration. RPV's actions may represent an effective strategy to treat chronic liver diseases of different aetiologies and help identify novel therapeutic targets.

Keyphrases

liver fibrosis
cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
cell proliferation
stem cells
oxidative stress
pi k akt
mouse model
liver injury
hiv infected patients
drug induced