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Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis.

Avraham UntermanAmy Y ZhaoNir NeumarkJonas C SchuppFarida AhangariCarlos CosmePrapti SharmaJasper FlintYan SteinChangwan RyuGenta IshikawaTomokazu S SumidaJose L GomezJose Herazo-MayaCharles S Dela CruzErica L HerzogNaftali Kaminski
Published in: medRxiv : the preprint server for health sciences (2023)
The single-cell atlas of the peripheral immune system in IPF, reveals an outcome-predictive increase in classical monocytes and Tregs, as well as evidence for a lung-blood immune recruitment axis involving CCL7 (for classical monocytes) and CCL18/CCL22 (for Tregs).
Keyphrases
  • single cell
  • idiopathic pulmonary fibrosis
  • rna seq
  • liver fibrosis
  • liver injury
  • high throughput
  • interstitial lung disease
  • drug induced
  • dendritic cells
  • peripheral blood
  • multiple sclerosis
  • copy number
  • gene expression