Distinguishing the contributions of neuronal and mucosal serotonin in the regulation of colonic motility.

Martin M AlyceLauren A JonesLai WeiNicholas J Spencer Kenton M Sanders Seungil Ro Damien J Keating

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)

We demonstrate that mucosal 5-HT release plays an important role in distension-evoked colonic motility, and that SERT inhibition no longer alters gut motility when EC cells are absent, thus demonstrating that ENS 5-HT does not play a role in regulating gut motility.

Keyphrases

biofilm formation
ulcerative colitis
induced apoptosis
pseudomonas aeruginosa
escherichia coli
candida albicans
signaling pathway
subarachnoid hemorrhage
blood brain barrier
cerebral ischemia