A polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies.

Maribel Aranda-GuillénEllen Christine RøyrvikSara Fletcher-SandersjööHaydee ArtazaIleana Ruxandra BotusanMarianne A GrytaasÅsa HallgrenLars BreivikMaria PetterssonAnders P JørgensenAnna LindstrandElinor VogtEystein S HusebyeOlle KämpeAnette S Bøe WolffSophie BensingStefan JohanssonDaniel Eriksson

Published in: Journal of internal medicine (2023)

The PRS performed well for case-control differentiation and susceptibility estimation in individual patients. Remarkably, a PRS for AAD holds promise as a means to detect disease etiologies other than autoimmunity. This article is protected by copyright. All rights reserved.

Keyphrases

case control
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
patient reported outcomes
big data
machine learning