Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder.
Kazuya YamashitaMakoto KinoshitaKatsuichi MiyamotoAkiko NambaMikito ShimizuToru KodaTomoyuki SugimotoYuki MoriYoshichika YoshiokaYuji NakatsujiAtsushi KumanogohSusumu KusunokiHideki MochizukiTatsusada OkunoPublished in: Journal of neuroinflammation (2018)
Extracellular mtDNA is specifically elevated in the CSF of patients with acute phase NMOSD, and mtDNA released by AQP4-Ab-mediated cellular damage elicits the innate immune cascades via TLR9 and NLRP3 inflammasomes pathways. Our study highlights mtDNA-mediated innate immune pathways as a novel therapeutic target for future treatment of NMOSD patients.
Keyphrases
- mitochondrial dna
- innate immune
- copy number
- cerebrospinal fluid
- end stage renal disease
- spectrum disorder
- ejection fraction
- newly diagnosed
- chronic kidney disease
- toll like receptor
- inflammatory response
- peritoneal dialysis
- genome wide
- oxidative stress
- dna methylation
- patient reported outcomes
- smoking cessation
- combination therapy