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Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study.

Rebecca McDonaldUlrike LorchJo WoodwardBjörn BosseHelen DoonerGill MundinKevin SmithJohn Strang
Published in: Addiction (Abingdon, England) (2017)
Concentrated 2 mg intranasal naloxone is well-absorbed and provides early exposure comparable to 0.4 mg intramuscular naloxone, following the 0.4 mg intramuscular curve closely in the first 10 minutes post-dosing and maintaining blood levels above twice the intramuscular reference for the next 2 hours.
Keyphrases
  • chronic pain
  • pain management
  • chronic rhinosinusitis