Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Fu PengNan ZhangChunting WangXiaoyun WangWei HuangCheng PengGu HeBo Han
Published in: Cell proliferation (2019)
Our findings lay a foundation for the application of a TNFα inhibitor and BNIP3 to aconitine-induced cardiac toxicity prevention and therapy, thereby demonstrating potential for further investigation.