Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: A study of urinary tract infection patients in Kenya, Tanzania and Uganda.
Keina SadoKatherine KeenanAreti ManatakiMike KesbyMartha F MushiStephan E MshanaJoseph R MwangaStella NeemaAsiimwe B BenonJoel BaziiraJohn N KiiruDominique L GreenXuejia KeAntonio Maldonado-BarraganMary Abed Al AhadKathryn FredricksStephen H GillespieWilber SabiitiBlandina Theophil MmbagaGibson KibikiDavid AanensenV Anne SmithAlison SandemanDerek J SloanMatthew Tg Holdennull nullPublished in: medRxiv : the preprint server for health sciences (2023)
The results highlight challenges East African patients face in accessing effective UTI treatment. These challenges increase where rates of MDR UTI are higher, suggesting a reinforcing circle of failed treatment attempts and sustained selection for drug resistance. Whilst individual behaviours may contribute to the risk of MDR UTI, our data show that factors related to context are stronger drivers of ABR.