A phase Ib feasibility trial of response adapted neoadjuvant therapy in gastric cancer (RANT-GC).
Farshid DayyaniBrian R SmithNinh T NguyenShaun DalyMarcelo W HinojosaSteven N SeyedinJeffrey KuoJason B SamarasenaJohn G LeeThomas H TaylorMay T ChoMaheswari SenthilPublished in: Future oncology (London, England) (2022)
Current guidelines recommend neoadjuvant (NAC) and/or adjuvant chemotherapy for locally advanced gastric cancers (LAGCs). However, the choice and duration of NAC regimen is standardized, rather than personalized to biologic response, despite the availability of several different classes of agents for the treatment of gastric cancer (GC). The current trial will use a tumor-informed ctDNA assay (Signatera™) and monitor response to NAC. Based on ctDNA kinetics, the treatment regimen is modified. This is a prospective single center, single-arm, open-label study in clinical stage IB-III GC. ctDNA is measured at baseline and repeated every 8 weeks. Imaging is performed at the same intervals. The primary end point is the feasibility of this approach, defined as percentage of patients completing gastrectomy.
Keyphrases
- transcription factor
- open label
- clinical trial
- phase iii
- study protocol
- rectal cancer
- end stage renal disease
- phase ii
- lymph node
- newly diagnosed
- locally advanced
- rheumatoid arthritis
- high resolution
- chronic kidney disease
- high throughput
- squamous cell carcinoma
- stem cells
- peritoneal dialysis
- patient reported outcomes
- phase ii study
- photodynamic therapy
- mass spectrometry
- combination therapy
- circulating tumor cells