Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.

Vincent VanheuleHelena CrijnsFariba PoostiPieter RuytinxNele BerghmansTanja GerlzaIsabelle RonsseNoëmie PörtnerPatrick MatthysAndreas J KunglGhislain OpdenakkerSofie StruyfMieke Gouwy

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)

The CXCL9(74-103) peptide inhibited dinitrofluorobenzene-induced infiltration of neutrophils and neutrophil-dependent inflammation in ears. Therefore, CXCL9(74-103) may be a lead molecule for the development of therapeutic peptides or peptide derivatives that compete with functional chemokines for GAG binding.

Keyphrases

high glucose
diabetic rats
drug induced
oxidative stress
type diabetes
insulin resistance