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The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin.

Philippe GodinMayra F TsoiMartin MorinNicolas GévryDerek Boerboom
Published in: Cell communication and signaling : CCS (2022)
Overall, these results indicate that Hippo collaborates with the cAMP/PKA and ERK1/2 pathways to participate in the precise regulation of the LH cascade, and that Areg, as a direct transcriptional target of YAP1, is involved in mediating its actions in the ovary. Video Abstract.
Keyphrases
  • single cell
  • signaling pathway
  • cell proliferation
  • cell therapy
  • gene expression
  • transcription factor
  • polycystic ovary syndrome
  • pi k akt
  • binding protein
  • type diabetes
  • stem cells