Familial risk for major depression: differential white matter alterations in healthy and depressed participants.
Alexandra WinterKatharina ThielSusanne MeinertHannah LemkeLena WaltemateFabian BreuerRegina CulemannJulia-Katharina PfarrFrederike SteinKatharina BroschTina MellerKai Gustav RingwaldFlorian Thomas-OdenthalAndreas JansenIgor NenadićAxel KrugJonathan ReppleNils OpelKatharina DohmElisabeth Johanna LeehrDominik GrotegerdHarald KugelTim HahnTilo T J KircherUdo DannlowskiPublished in: Psychological medicine (2022)
We found widespread increased FA in HC with familial risk for MDD as compared to a HC low-risk sample. The significant effect of risk on FA was present only in HC, but not in the MDD sample. These alterations might reflect compensatory neural mechanisms in healthy adults at risk for MDD potentially associated with resilience.