Familial risk for major depression: differential white matter alterations in healthy and depressed participants.

Alexandra Winter Katharina ThielSusanne MeinertHannah Lemke Lena WaltemateFabian BreuerRegina CulemannJulia-Katharina Pfarr Frederike Stein Katharina Brosch Tina Meller Kai Gustav Ringwald Florian Thomas-OdenthalAndreas JansenIgor Nenadić Axel Krug Jonathan Repple Nils Opel Katharina Dohm Elisabeth Johanna Leehr Dominik Grotegerd Harald KugelTim HahnTilo T J Kircher Udo Dannlowski

Published in: Psychological medicine (2022)

We found widespread increased FA in HC with familial risk for MDD as compared to a HC low-risk sample. The significant effect of risk on FA was present only in HC, but not in the MDD sample. These alterations might reflect compensatory neural mechanisms in healthy adults at risk for MDD potentially associated with resilience.

Keyphrases

major depressive disorder
white matter
early onset
multiple sclerosis
bipolar disorder