Exercise as an Immune Boost: Mechanism-Driven Support for Lifestyle Interventions.
Allison Betof WarnerPublished in: Cancer immunology research (2023)
Modifiable host factors have demonstrated promise to enhance responses to immunotherapy. In this issue, Savage et al. investigated the use of aerobic exercise to enhance antitumor immunity in a murine model of melanoma. They show that treadmill running improves tumor vasculature and alters both T-cell and myeloid-cell infiltration of the tumor via an ERK5-dependent mechanism, adding to the growing evidence supporting the immune-mediated antitumor effects of exercise. See related article by Savage et al. (3).
Keyphrases
- high intensity
- physical activity
- signaling pathway
- single cell
- metabolic syndrome
- resistance training
- cardiovascular disease
- bone marrow
- cell proliferation
- acute myeloid leukemia
- cell therapy
- dendritic cells
- weight loss
- pi k akt
- big data
- machine learning
- immune response
- mesenchymal stem cells
- atomic force microscopy
- stem cells
- body composition
- artificial intelligence