Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review.

Nikita HanningAdam L EdwinsonHannah CeuleersStephanie A PetersJoris G De ManLeslie C HassettBenedicte Y De Winter Madhusudan Grover

Published in: Therapeutic advances in gastroenterology (2021)

Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

Keyphrases

irritable bowel syndrome
abdominal pain
case control
oxidative stress
young adults