Evaluation of the indication of BRCA1/2 genetic tests in Iranian women and acceptance rate of risk-reducing surgeries in BRCA mutation carriers.

Mahtab VasighBita EslamiAhmad ElahiAhmad KavianiReza ShirkoohiKeivan MajidzadehNewsha NazarianRamesh Omranipour

Published in: Molecular genetics & genomic medicine (2022)

If the onset of breast cancer at a young age (less than 40) will be the only indication for a BRCA analysis, the rate of a positive result (12.8%) is very low. Further studies are warranted to evaluate the age limit for genetic testing in our country. Prophylactic mastectomy acceptance is very low in BRCA1/2 carriers in our centers.

Keyphrases

breast cancer risk
genome wide
young adults
pregnant women
copy number
pregnancy outcomes
middle aged