Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.
Lynne KrohnRichard Y J WuKarl HeilbronJennifer A RuskeySandra B LaurentCornelis BlauwendraatArmaghan AlamIsabelle ArnulfMichele T M HuYves DauvilliersBirgit HöglMathias ToftKari Anne BjørnaråAmbra StefaniEvi HolzknechtChristelle Charley MonacaBeatriz AbrilGiuseppe PlazziElena AntelmiLuigi Ferini-StrambiPeter YoungAnna HeidbrederValérie Cochen De CockBrit MollenhauerFriederike Sixel-DöringClaudia TrenkwalderKarel SonkaDavid KemlinkMichela FigorilliMonica PulighedduFemke DijkstraMineke ViaeneWolfang OertelMarco ToffoliGian Luigi GigliMariarosaria ValenteJean-François GagnonMike A NallsAndrew B Singletonnull nullAlex DesautelsJacques Y MontplaisirPaul CannonOwen A RossBradley F BoeveNicolas DupréEdward A FonRonald B PostumaLasse PihlstrømGuy A RouleauZiv Gan OrPublished in: Annals of neurology (2020)
There is a distinct pattern of association at the SNCA locus in RBD as compared to PD, with an opposite direction of effect at the 3' of SNCA. Several 5' SNCA variants are associated with iRBD and with pRBD in overt synucleinopathies. ANN NEUROL 2020;87:584-598.