Prenatal alcohol exposure promotes NLRP3 inflammasome-dependent immune actions following morphine treatment and paradoxically prolongs nerve injury-induced pathological pain in female mice.

Shahani NoorMelody S SunAndrea A PasmayAriana N PrithaChaselyn D Ruffaner-HansonMonique V NysusDiane C JimenezMinerva MurphyDaniel D SavageC Fernando ValenzuelaErin D Milligan

Published in: Alcohol, clinical & experimental research (2023)

In female mice, PAE prolongs allodynia following morphine treatment through NLRP3 activation. TLR4-activated PAE immune cells showed enhanced IL-1β release with morphine via NLRP3 actions. Similar studies are needed to examine the adverse impact of morphine in males with PAE. These results are predictive of adverse responses to opioid pain therapeutics in individuals with FASD.

Keyphrases

nlrp inflammasome
chronic pain
pain management
neuropathic pain
pregnant women
high fat diet induced
small molecule
toll like receptor
inflammatory response
spinal cord
combination therapy
replacement therapy
electronic health record
spectrum disorder