Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma.
Elena I FomchenkoBenjamin C ReevesWilliam SullivanAsher M MarksAnita HuttnerKristopher T KahleE Zeynep Erson-OmayPublished in: Molecular genetics & genomic medicine (2021)
Similar variant allele frequencies of FGFR1 p.K656E and FGFR1 p.V561M mutations in our patient's tumor suggest that these mutations may have occurred at similar time points. Use of FGFR inhibitors in addition to STAT3 or PI3K/mTOR inhibition may prove a useful strategy in targeting our patient's pilomyxoid astrocytoma.