Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus.
Sarah ReidNiklas HagbergJohanna K SandlingAndrei AlexssonPascal PucholtChristopher SjöwallKaroline LerangAndreas JönsenIva GunnarssonAnn-Christine SyvänenAnne Margrethe TroldborgAnne VossAnders A BengtssonØyvind MolbergSøren JacobsenElisabet SvenungssonLars RönnblomDag LeonardPublished in: Annals of the rheumatic diseases (2021)
Smoking in the presence of the STAT4 risk gene variant appears to increase the risk of MI and nephritis in SLE. Our results also highlight the role of the IL12-STAT4 pathway in SLE-cardiovascular morbidity.