Serum neurofilament light chain levels as a marker of upper motor neuron degeneration in patients with Amyotrophic Lateral Sclerosis.
Benjamin GilleM De SchaepdryverJ GoossensL DedeeneJ De VochtE OldoniA GorisL Van Den BoschB DepreitereK G ClaeysJ TournoyP Van DammeK PoesenPublished in: Neuropathology and applied neurobiology (2018)
Altogether, these findings suggest that elevated serum NfL levels in ALS are driven by UMN degeneration and the disease progression rate and are independently associated with survival at time of diagnosis.
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