Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.

Laura I NeumeierRobert B ThomsonMartin ReichelKai-Uwe EckardtPeter S AronsonFelix Knauf

Published in: Journal of the American Society of Nephrology : JASN (2020)

Slc26a6-mediated enteric oxalate secretion is critical in decreasing the body burden of oxalate in murine CKD models. Future studies are needed to address whether similar mechanisms contribute to intestinal oxalate elimination in humans to enhance extrarenal oxalate clearance.

Keyphrases

chronic kidney disease
end stage renal disease
current status
risk factors
peritoneal dialysis
case control