Chemical composition and biological activities of essential oil from Grewia bulot leaves.

This study focused on the chemical composition and biological activities of the essential oil derived from Grewia bulot , a plant species known for its medicinal properties. The analysis of Grewia bulot essential oil revealed the presence of 78 constituents. The major compounds were α -cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di- epi -cubenol (9.8%), epi - α -cadinol (6.7%), ( E , E )- α -farnesene (5.9%), ( E )-citral (4.0%), selin-11-en-4- α -ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC 50 value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC 50 values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.