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Colchicine causes prenatal cell toxicity and increases tetraploid risk.

Ding WangYingjun XieMinyi YanQianying PanYi LiangXiao-Fang Sun
Published in: BMC pharmacology & toxicology (2019)
Our study revealed the results of a colchicine-induced toxicity test in prenatal cells and determined the anti-mitotic biologically functional dose and manner of administration that might reduce the risk of tetraploid generation.
Keyphrases
  • pregnant women
  • single cell
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • diabetic rats
  • high glucose
  • cell therapy
  • cell cycle
  • cell death
  • endoplasmic reticulum stress
  • mesenchymal stem cells
  • pi k akt